Appetite regulation and the dysregulation of appetite hormones play a crucial role in the development and perpetuation of obesity. Hormones, including ghrelin, leptin, and glucagon-like peptide-1 (GLP-1), are key players in this process and as such, have been targeted by pharmaceutical companies. Dysregulation of these hormones can disrupt the balance between energy intake and expenditure, contributing to overeating and weight gain.
Multiple hormonal signals influence appetite:
1. Ghrelin:
2. Leptin:
3. GLP-1 (Glucagon-Like Peptide-1):
The regulation of appetite is highly complex and influenced by various factors, including genetics, lifestyle, and environmental factors, as previously discussed. The dysregulation of these appetite hormones is just one aspect of the multifaceted nature of obesity. Understanding how these appetite hormones work and how they are influenced by obesity is important to consider when developing your clinic’s weight management program.8 – 12
Secretion and expression of GLP-1 throughout the body
References: